Este cuestionario hasta el martes

Lea el siguiente articulo y en base a la lectura responda:

1. ¿A que se refiere con integridad de los puntos de control?

2. ¿Qué mecanismo utiliza p53 para detener el ciclo celular?

3. ¿Qué complejo es el responsable de la modificación de la H1?

4. ¿Qué complejo inactiva a pRB?

De acuerdo a este fragmento:

Inhibition of replication elongation caused by a variety of adverse situations, including depletion of dNTPs or DNA damage, leads to arrest and disruption of replication forks, induction of the SOS response, and genomic instability (Michel et al., 2004 and references therein). We found that the replication forks arrested by (p)ppGpp did not detectably recruit RecA, indicating that the forks were probably not disrupted. We suggest that (p)ppGpp-mediated replication arrest contributes to the maintenance of genomic stability by preventing disruptive fork arrest that might otherwise occur with uncontrolled replication during starvation. (Nutritional Control of Elongation of DNA Replication by (p)ppGpp). Author links open overlay panel Jue D.Wang¹³Glenn M.Sanders² Alan D.Grossman

5. ¿Cual es la intervención de ppGpp en la fase S?

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